Research Assistant, UCD School of Biomolecular and Biomedical Science, 011163

Job Ref: 011163

Position Summary
The Research Assistant will evaluate the safety and efficacy of plant-based extracts in zebrafish models of impaired vision. The research assistant will determine if the highest tolerated dose of specific plant extracts is neuroprotective in a zebrafish model of inherited blindness. All assays using zebrafish will be conducted by authorised individuals under appropriate UCD ethical exemptions or HPRA project authorisations.

Appointment on the above range will be dependent upon qualifications and experience.

Principal Duties and Responsibilities
Research assistant duties will include, but not be limited to the following:

  • Maintain specific strains of zebrafish linked with genetic forms of impaired vision;
  • To assess the tolerability of 4-10 plant derived extracts in wildtype zebrafish larvae;
  • Test if the determined highest tolerated dose of 4-10 of the extracts is neuroprotective in a zebrafish model of inherited blindness;
  • Assess visual behaviour in zebrafish by the optokinetic response assay (OKR);
  • Validate studies using:
  • dose-response analysis of the effects of the plant extracts in zebrafish using optokinetic and visualmotor response assays;
  • assessing effects on retinal histology by light microscopy analysis and iv) effects on gene expression using real-time PCR.
  • Undertake any other duties as assigned by the Principal Investigator or nominee.

Selection Criteria
Selection criteria outline the qualifications, skills, knowledge and/or experience that the successful candidate would need to demonstrate for successful discharge of the responsibilities of the post. Applications will be assessed on the basis of how well candidates satisfy these criteria.

Mandatory

  • A BSc or MSc in a scientific discipline related to pharmacology;
  • A track-record of working independently and within a team;
  • Excellent time management and organisation skills;
  • Experience in biomedical testing of plant-derived extracts;
  • Experience in the evaluation of drug activity;
  • A track record demonstrating an appreciation of drug commercialisation.

Desirable

  • Experience in the use of zebrafish as a research model;
  • Individual authourisation from the HPRA;
  • Expertise in vision research;
  • Industry experience;
  • A track record demonstrating an appreciation of drug commercialisation.


Société

University College Dublin

Lieux

Catégories

Dernier jour de candidature

2019-03-22


Postuler à l'offre



Société

University College Dublin

Lieux

Catégories

Dernier jour de candidature

2019-03-22


Postuler à l'offre